pharmaceutical intermediates

Azithromycin

Identification
Name Azithromycin
Synonyms 9-Deoxo-9a-methyl-9a-aza-homoerythromycin A; (2R,3S,4R,5R,8R,10R,11R,13S,14R)-11-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one
copyRight
Molecular Structure CAS # 83905-01-5, Azithromycin, 9-Deoxo-9a-methyl-9a-aza-homoerythromycin A, (2R,3S,4R,5R,8R,10R,11R,13S,14R)-11-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one
Molecular Formula C38H72N2O12
Molecular Weight 748.99
CAS Registry Number 83905-01-5
INQUIRY

product Description:

Azithromycin is antibiotics.The antibacterial spectrum of this product is similar to erythromycin, with strong effect on haemophilus influenzae and gonococci, which is 4 times stronger than erythromycin.Twice as strong for legionella;For the vast majority of gram-negative bacteria, the effect on clostridium difficile is also stronger than erythromycin, in the application of staphylococcus aureus infection is also more effective than erythromycin.In addition, this product also has a good killing effect on toxoplasmosis, treponema pallidum.

Manufacturer Supply Azithromycin CAS83905-01-5 Azithromycin API

Specification

Items	Specifications	Results
Appearance	White or almost white powder	White powder
Solubility	Practically insoluble in water, freely soluble in anhydrous ethanol and in methylene chloride	Conforms
Idetification	1) IR: Conforms to the spectrum of Azithromycin RS	Conforms
Idetification	2) HPLC: The retention time of azithromycin peak in the chromatogram of the assay preparation corresponds to that in the chromatogram of the Standard preparation, as ovtained in the assay	Conforms
Specific rotation	-45°~ -49°	-47°
Crystallinity	Meets the requirements	Conforms
pH	9.0~11.0 (2mg/ml methanol-water(1:1))	10.1
Water	4.0%~5.0%	4.60%
Residue on ignition	≤0.3%	0.01%
Heavy metals	≤25ppm	<25ppm
	Impurity A ≤0.5%	Not detected
	Impurity B ≤1.0%	0.40%
	Impurity C ≤0.5%	0.22%
	Impurity J ≤0.3%	0.11%
	Impurity E ≤0.5%	Not detected
	Impurity F ≤0.5%	<0.10%
	Impurity G ≤0.5%	Not detected
Related Substances(HPLC Test 2)	Impurity I ≤0.7%	Not detected
	Impurity L≤0.5%	Not detected
	Impurity M≤0.5%	Not detected
	Impurity N ≤0.5%	Not detected
	Impurity O≤0.5%	0.11%
	Impurity P ≤0.2%	<0.10%
	Any other impuirty ≤0.2%	<0.10%
	Total impurities ≤3.0%	0.84%
Residual Solvents	Methylene Chlorde≤600ppm	Not detected
Residual Solvents	Acetone ≤5000ppm	330ppm
Assay	945~1030μg/mg (Anhydrous substance )	978μg/mg
Conclusion	The results can conforms with the USP37 standard.

Application

1.Azithromycin is used to treat or prevent certain bacterial infections, most often those causing middle ear i nfections, strep throat, pneumonia, typhoid, and sinusitis;

2.It has been used primarily to prevent bacterial infections in infants and those with weaker immune system

3.It is also effective against certain sexually transmitted infections, such as non- gonococcal urethritis, chlamydia, and cervicitis;

4.Azithromycin is used for acute pharyngitis, acute tonsillitis caused by Streptococcus pyogenes;

5.Azithromycin is used for acute throat and tonsillitis which are caused by streptococcus pyogenes, otitis;

6.Azithromycin can treatment of media sinusitis acute bronchitis skin soft tissue infection which are caused by sensitive bacteria;

7.Azithromycin is also used for pneumonia urethritis cervicitis and so on.

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