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  • Paclitaxel

Paclitaxel

  • Identification
  • Name Paclitaxel
  • Synonyms 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete benzenepropanoic acid deriv.; Taxal; Taxol A
  • copyRight
  • Molecular Structure CAS # 33069-62-4, Paclitaxel, 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete benzenepropanoic acid deriv., Taxal, Taxol A
  • Molecular Formula C47H51NO14
  • Molecular Weight 853.92
  • CAS Registry Number 33069-62-4
  • INQUIRY


Products Description 


Product Name:Paclitaxel
Other NameTaxol
Source: taxus
Part of Used:bark
Test Method:HPLC
Specification:98% 99%
CAS:33069-62-4
MF:C47H51NO14
MW:853.91
EINECS608-826-9
Appearance:Fine Powder
Taste:Characteristic
Supplier Name:ShaanXi Greenyo Biotech Co.,Ltd
Shelf Life:2 years
Package:1kg/foil bag(net weight 1kg, gross weight 1.2kg), 25kg/fiber drum(net weight 25kg, gross weight 28kg)
Storage:Stored in a cool and dry well closed container and in ventilated area, kept away from moisture and strong light or high temperature.


Function

Paclitaxel is a monomer diterpene extracted from the bark of taxus, a natural plant. It is a complex secondary metabolite and the only known drug that can promote and stabilize the polymerized microtubules.Isotopic tracers indicate that paclitaxel binds only to the polymerized tubules and does not react with the unpolymerized tubuloprotein dimer.Cells exposed to paclitaxel accumulate a large number of microtubules, which interfere with the cell's various functions, especially by stopping cell division at the mitotic stage and preventing normal cell division.Through the II-III clinical research, paclitaxel is mainly suitable for ovarian cancer and breast cancer, to lung cancer, colorectal cancer, melanoma, head and neck cancer, lymphoma, brain tumors also has certain curative effect.

Application

It has a good effect on refractory ovarian cancer and breast cancer with drug resistance such as ovarian cancer and platinum, and a good prospect for the treatment of prostate cancer, head and neck cancer, esophageal cancer, germ cell tumor, endometrial cancer, lymphoma, bladder cancer, upper digestive tract cancer, small cell and non-small cell lung cancer.


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